Resection of piriform cortex predicts seizure freedom in temporal lobe epilepsy

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Seizure freedom off antiepileptic drugs after temporal lobe epilepsy surgery

Data are limited on seizure recurrence after antiepileptic drug (AED) discontinuation in operated seizure-free patients. We reviewed seizure outcome in patients who came off AEDs after being seizure-free for 2 years following temporal lobe surgery in our center. Thirty-nine (68%) of 57 patients who discontinued AED therapy remained seizure-free. They had a younger age at surgery than the group ...

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Endoscopic Transsphenoidal Resection of a Medial Temporal Arachnoid Cyst in a Patient with Temporal Lobe Epilepsy

Abstract Introduction: Arachnoid cysts are developmental cystic lesions which may be found as an incidental finding on neuroimaging or present with symptoms of headache, seizure and neurologic deficit. Presentation with seizure is more common with larger sizes and temporal location. Presentation with TLE is rare, and fenestration of cysts had variable results for seizure control. Here in, we r...

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Structural changes in the temporal lobe and piriform cortex in frontal lobe epilepsy

BACKGROUND Neuronal networks involved in seizure generation, maintenance and spread of epileptic activity comprise cortico-subcortical circuits. Although epileptic foci vary in location across focal epilepsy syndromes, there is evidence for common structures in the epileptogenic networks. We recently reported evidence from functional neuroimaging for a unique area in the piriform cortex, common...

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MR volumetric analysis of the piriform cortex and cortical amygdala in drug-refractory temporal lobe epilepsy.

BACKGROUND AND PURPOSE The assessment of patients with temporal lobe epilepsy (TLE) traditionally focuses on the hippocampal formation. These patients, however, may present structural abnormalities in other brain areas. Our purpose was to develop a method to measure the combined volume of the human piriform cortex and cortical amygdala (PCA) by using MR imaging and to investigate PCA atrophy. ...

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Resection extent versus postoperative outcomes of seizure and memory in mesial temporal lobe epilepsy

OBJECTIVES To investigate the effects of the resection of hippocampus and temporal neocortex on postsurgical seizure and memory outcomes in mesial temporal lobe epilepsy (mTLE) patients. METHODS Sixty-eight mTLE patients underwent pre- and postsurgical brain magnetic resonance imaging (MRI). The patients were divided into seizure-free group (SF, N=54) and non-seizure-free group (NSF, N=14). T...

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ژورنال

عنوان ژورنال: Annals of Clinical and Translational Neurology

سال: 2020

ISSN: 2328-9503,2328-9503

DOI: 10.1002/acn3.51263